Basic information:
Chemical formula: C₁₁H₁₄N₂O
Molecular weight: 190.24
Appearance: Grayish-white to yellowish-brown crystalline solid, or orthorhombic prismatic powder
Melting point: 154-156℃
Toxicity: It has certain toxicity and should be used with caution
● Respiratory excitation: Its effect on the respiratory system is similar to that of nicotine. It can reflexively excite the respiratory center, enhance the depth and frequency of breathing, and its effect of stimulating breathing is stronger than that of the same dose of phellodenine
● Anti-arrhythmic: It can reduce myocardial irritability and conductivity, slow heart rate, inhibit myocardial contractility, and prolong the refractory period. It can be used to treat ventricular tachycardia and functional palpitations
● Other functions: Recent studies have shown that it also has multiple pharmacological activities such as anti-microbial infection, anti-ulcer, increasing white blood cells, and anti-cancer. In terms of anti-cancer activity, it can induce apoptosis of cancer cells and has been widely used to inhibit the proliferation of various tumor cells
● Smoking cessation effect: Plantarine is a alkaloid with high binding affinity to the nicotine-acetylcholine receptor. It can act as a selective local agonist, reducing smokers' dependence on nicotine, alleviating the urge to smoke, and reducing the severity of nicotine withdrawal symptoms
● Respiratory excitatory effect: The effect of metronidine on the respiratory system is similar to that of nicotine. It can reflexively excite the respiratory center, enhancing the depth and frequency of breathing
● Anti-arrhythmic effect: Clindamine can reduce myocardial irritability and conductivity, slow heart rate, inhibit myocardial contractility, and prolong the refractory period, thus being used to treat ventricular tachycardia and functional palpitations.
● Anti-cancer effect: Plantarine can induce apoptosis of cancer cells and inhibit the proliferation of various tumor cells in terms of anti-cancer activity
● Other functions: Clindamine also has the effects of anti-microbial infection, anti-ulcer, increasing white blood cells, improving cognitive function, and anti-depression
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