Dihydromyricetin (DHM) is a flavonoid compound extracted from plants of the genus Ophiophora in the Vitaceae family (such as Ophiophora dentata, commonly known as vine tea), which has multiple pharmacological activities and broad application prospects.
I. Chemical Properties and Sources
l Chemical formula: C₁₅H₁₂O₈, molecular weight 320.25.
l Appearance: White needle-like crystals, readily soluble in hot water, hot ethanol and acetone, slightly soluble in ethyl acetate, insoluble in chloroform and petroleum ether.
l Stability: It is stable under neutral and slightly acidic conditions and has good thermal stability. However, irreversible oxidation reactions will occur when the temperature exceeds 100℃.
l Source: It mainly exists in the young stems and leaves of the variegata serrata, with a content of up to 30% (by mass fraction). In addition, plants of the Myricaceae and Rhododendron families also contain small amounts of dihydromyricetin.
Ii. Pharmacological Activity
l Antioxidant effect
It can eliminate free radicals in the body, reduce the damage of free radicals to cells and tissues, and delay aging.
Experiments show that dihydromyricetin with a purity of 98% can significantly inhibit the production of malondialdehyde (MDA) in rat myocardial, liver and brain tissues, and the inhibitory effect increases with the increase of concentration.
l Anti-inflammatory effect
By regulating inflammatory response-related factors (such as interleukin-1 β, tumor necrosis factor -α, etc.), it reduces the activity of inflammatory cells and alleviates inflammatory symptoms.
Experiments on mouse auricular swelling and writhing experiments showed that dihydromyricetin could significantly inhi
l It has the effect of sobering up and protecting the liver
Accelerate the decomposition of acetaldehyde, a metabolite of ethanol, and reduce its damage to liver cells.
Improve liver cell damage, inhibit liver fibrosis, and reduce the irritation of alcohol on the liver.
Clinical trials have shown that dihydromyricetin can inhibit the activity of alcohol dehydrogenase, enhance the synthesis ability of aldehyde dehydrogenase, and accelerate the decomposition of alcohol in a dual way.
l Regulate blood lipids and blood sugar
Inhibit the increase of blood glucose in mice induced by alloxanil, epinephrine, etc., and simultaneously increase the serum insulin level.
For streptoamycin-induced hyperglycemia rats, it can reduce the content of serum triglycerides (TG), but has no significant effect on total cholesterol (TC) and high-density lipoprotein cholesterol (HDL-C).
l antibacterial action
It has antibacterial effects on various bacteria such as Bacillus subtilis, Staphylococcus aureus, Salmonella, Escherichia coli, as well as yeasts and molds, especially showing significant effects on Gram-positive and Gram-negative cocci or bacilli
l anti-tumor effect
By inhibiting the growth of tumor blood vessels and regulating cellular immune function, it exerts activity against various tumors such as leukemia, nasopharyngeal carcinoma and liver cancer.
It can induce apoptosis of tumor cells, inhibit proliferation and migration of tumor cells, and reverse drug resistance of tumor cells.
At present, dihydromyricetin has entered the clinical trial stage of anti-tumor drugs
l boost immunity
Activate immune cells, promote the production of immune factors, enhance the function of the immune system, and prevent colds and other infectious diseases.
Iii. Application Fields
l health care products
It is widely used in health products for alcohol detoxification and liver protection, such as Jiangzhong Liver Pure Tablets and DihydroYangmeisu Alcohol Detoxification and Liver Protection Capsules, etc.
As an antioxidant, anti-inflammatory and lipid-blood sugar regulating ingredient, it is used for daily health care
l Cosmetics
It has whitening effects, can inhibit the activity of tyrosinase and reduce the production of melanin.
By means of embedding or acylation and esterification modification, its water solubility is improved, making it suitable for cosmetics in both oil and ethanol systems.
l medicine
It is used to prepare anti-tumor drugs, such as ophistatin injection, providing new treatment options for patients with leukemia and nasopharyngeal carcinoma.
Develop Chinese patent medicine preparations for the treatment of respiratory tract infections and alcoholism, such as tablets, capsules and granules.
l feed supplement
As a green, natural, non-toxic and side-effect-free additive, it is used in animal husbandry to enhance the growth performance and immune function of animals.
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Post time: Feb-28-2026