Nicotinamide mononucleotide (NMN) and nicotinamide adenine dinucleotide (NAD+, coenzyme I) are anti-aging ingredients that have become popular worldwide in the past five years. After oral administration, NMN is converted into NAD+in the body to exert its anti-aging effects. β – nicotinamide mononucleotide (NMN) is a naturally occurring bioactive nucleotide with strong potential in the treatment of cardiovascular and cerebrovascular diseases, liver and kidney function, vascular and endothelial function, as well as various diseases such as immunity, inflammation, and aging. It is often referred to as a “panacea”.
The association between NMN and anti-aging has a long history
Pursuing health and deciphering the mysteries of aging seems to be an eternal research topic for humanity. In 1931, chemists Conrad and Elvijm discovered that niacin, a member of the vitamin B family, is an important precursor to coenzyme I (NAD+) in the human body and a relieving factor for treating pellagra. In 1959, using nuclear extracts from hens, French scientists discovered that coenzyme I could be broken down into two parts, one of which nicotinamide was recovered, while the other ADP ribose met with polymerase to form a protein that repairs cells. This study elucidates that the repaired proteins are dependent on coenzyme I.
In 2013, Professor David Sinclair from Harvard Medical School in the United States added a derivative of nicotinamide, NMN, to the feed of a group of mice. As a result, the animals’ vitality increased significantly, their ears and eyes became sharp, and their fur changed from white hair to shiny black, which could delay aging and extend lifespan by nearly 30%. The news was published in Time magazine and caused a sensation worldwide. Due to David Sinclair’s discovery of anti-aging substances, he was also named one of the “100 Most Influential People in the World” by Time magazine. Japan conducted two phase clinical studies in 2017, lasting one and a half years, aimed at confirming the health outcomes of long-term use of NMN. The first clinical confirmation shows that taking NMN in the human body has anti-aging effects. In 2018, in collaboration with research institutions such as the California Institute of Technology and the University of Pennsylvania, a company in the United States released a product, giving birth to a “miracle drug” NMN that can delay aging.
The NMN, also known as the “longevity gene,” is a naturally occurring nucleotide that is a precursor of nicotinamide adenine dinucleotide (Coenzyme I), a cofactor of human longevity protein. Its function is expressed through Coenzyme I. Coenzyme I is the most important substance for maintaining youthfulness in the human body and is also one of the essential molecules for sustaining life. It participates in nearly a thousand cellular metabolism and metabolic reactions in the human body and is an important supporting force for maintaining cell vitality.
NMN exists in two irregular forms, namely α and β, with the β isomer being its active structure. Given that nicotinamide belongs to vitamin B3, NMN is a derivative of the vitamin B family and is closely related to immunity, metabolism, aging, audio-visual function, pancreatic secretion function, and disease occurrence.
What are the benefits of NMN, known as the ‘longevity gene’
(1) Delaying aging, the journal Cell reported that after using NMN to increase coenzyme I levels for one week, 22 month old mice (equivalent to 60 years old in humans) showed significant differences compared to before, with similar levels in key indicators such as mitochondrial homeostasis and muscle health compared to 6-month-old mice (equivalent to 20 years old in humans). NMN has the function of delaying aging.
(2) Improving cardiovascular health not only enhances the function of myocardial and vascular cells, but also reduces blood lipid levels (triglycerides, cholesterol) and atherosclerotic plaque volume.
(3) NMN can promote mitochondrial function, including enhancing mitochondrial oxidative phosphorylation ability, increasing mitochondrial lipid oxidation, etc., which is beneficial for improving the cognitive level and memory of elderly dementia patients.
Throughout history, health and longevity have been the common aspirations of every generation, and in the future, more effective life technologies will continue to emerge. NMN is currently the first scientifically validated substance that can resist aging, but it is destined not to be the last. And one day, humans may also enjoy the benefits brought by the increasing popularity of life sciences, making health and longevity no longer just a dream.
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Post time: Mar-10-2026