Chii chinonzi Urolithin A? Ongorora mabhenefiti ayo nemashandisirwo

Kunzwisisa Urolithin A

Urolithin A is metabolite inogadzirwa negut microbiota kubva ku ellagitannins, inowanikwa mumichero yakasiyana-siyana, kunyanya matamba, majiroji, uye nzungu. Komisheni iyi yakwezva kutarisisa kwakawanda kune yayo inogona kubatsira hutano, kunyanya munzvimbo dzehutano hwemaserura, anti-kuchembera, uye metabolic basa.

Zvidzidzo zvenguva pfupi zvakaratidza kuti kutora 1 gramu yeUrolithin A zuva nezuva kwemavhiki masere kunogona kuvandudza zvakanyanya kusimba kwekuzvidira kwemhasuru uye kutsungirira. Kuwana uku kunoratidza kugona kwayo sekuwedzera kune simba kune avo vari kutsvaga kuvandudza mashandiro emuviri uye hutano hwese.

Mhedzisiro yeUrolithin A paKurara

Chimwe chezvinhu zvinonyanya kufadza zveUrolithin A kugona kwayo kuvandudza kunaka kwekurara. Zvidzidzo zvakaratidza kuti Urolithin A inogona kudzora rhythms cellular mumatanho akawanda, izvo zvakakosha pakuchengetedza hutano hwekurara-kumuka kutenderera. Munyika yedu yemazuva ano inomhanya-mhanya, vanhu vazhinji vanosangana ne "social jet lag" nekuda kwemaawa ekushanda asina kujairika, basa rekuchinja, uye kufamba nguva zhinji munzvimbo dzenguva. Urolithin A inoratidza chivimbiso mukuderedza izvi zvinokonzeresa, kubatsira vanhu kuwana kuzorora kwakanyanya, kudzoreredza kurara.

Nekuvandudza hutano hwekurara, Urolithin A haingobatsiri kuvandudza hutano hwemuviri, asiwo inosimudzira hutano hwepfungwa. Kurara kwemhando yepamusoro kwakakosha pakuita basa rekuziva, kudzora manzwiro, uye kugutsikana kwehupenyu hwese. Naizvozvo, kusanganisa Urolithin A muhupenyu hwezuva nezuva kunogona kushandura hupenyu kune avo vanotambura nezvinetso zvine chekuita nekurara.

Kuenzanisa uye kushandiswa kweNMN neNR

Nepo Urolithin A yakaita mafungu muindasitiri yekuwedzera, zvinodikanwa kuienzanisa nemamwe makomisheni anozivikanwa seNMN neNR. Ose ari maviri NMN neNR anotangira eNAD+ (nicotinamide adenine dinucleotide), yakakosha coenzyme inobatanidzwa musimba metabolism uye kugadzirisa masero.

NMN (Nicotinamide Mononucleotide): NMN inozivikanwa nekugona kwayo kuwedzera NAD + mazinga, ayo anogona kuwedzera kugadzirwa kwesimba, kuvandudza hutano hwemetabolism, uye kukurudzira hupenyu hurefu. Inowanzo tengeswa sechinhu chinopesana nekukwegura.

- NR (Nicotinamide Riboside): Yakafanana neNMN, NR imwezve NAD + precursor yakadzidzwa kune zvingangobatsira musimba remetabolism uye zvine chekuita nezera nyaya dzehutano.

Nepo zvese NMN neNR zvichitarisa kuwedzera NAD + mazinga, Urolithin A inopa yakasarudzika nzira nekusimudzira mitochondrial basa nekuvandudza hutano hwemhasuru. Izvi zvinoita kuti Urolithin A ive mubatsiri mukuru kuNMN neNR inopa maitiro akazara kune hutano uye hutano.

Remangwana reurolithin A

Sezvo tsvakiridzo ichiramba ichidzika, tarisiro yeUrolithin A yakajeka. Kugona kwayo kuvandudza kunaka kwekurara, kuwedzera simba, uye kutsigira kugara zvakanaka kunoita kuti ive yekuwedzera kukuru kumusika wekuwedzera.

Kambani yedu iri pamberi peiyi budiriro inonakidza, ichipa yemhando yepamusoro Urolithin A uye zvimwe zvigadzirwa zvitsva zvinotsigirwa netsvagiridzo yesainzi. Isu tinodada kuva neR&D yakasimba uye timu yekuongorora mhando kuti tive nechokwadi chekuti zvigadzirwa zvedu zvinosangana nemhando yepamusoro. Chikwata chedu chakazara chekutsvaga chinoshanda nesimba kuti tiwane akanakisa zvigadzirwa, kuve nechokwadi chekuti vatengi vedu vanongogamuchira zvigadzirwa zvemhando yepamusoro.

Tinogona here kuwana Urolithin A kubva muchikafu?

Iine mabasa ane simba zvakanyanya senge anti-kuchembera mhedzisiro, yakasimba antioxidant masimba, kugona kudzoreredza basa rekuchembera hematopoietic stem masero, kuwedzera kusadzivirirwa uye insulin senitivity, kudzosera kukuvara kwechiropa kana itsvo, kunonoka kuchembera kweganda, uye kudzivirira nekurapa chirwere cheAlzheimer. Tingaiwana here kubva muzvokudya zvepanyama?

Urolithin A is metabolite inogadzirwa ne intestinal microbiota kubva ellagitannins (ETs) uye ellagic acid (EA). Sezvineiwo, 40% chete yevanhu vanogona kuishandura kubva kune chaiwo masanganiswa mukudya kwavo kwezuva nezuva. Sezvineiwo, ma supplements anogona kukunda ichi chinogumira.